Although blue is considered the normal color for sapphires, they can be found across a full range of spectral colors as well as brown, colorless, grey and black. Those other than blue in color are considered fancy color sapphires. Some natural sapphires can be found as completely transparent, or "white." White sapphires usually come out of the ground as light grey or brown and are then heated to make them clear. However, in very rare circumstances they will be found in a clear state.

Various shades of blue [dark and light] result from titanium and iron substitutions in the aluminum oxide crystal lattice. Some stones are not well saturated and show tones of gray. It is common practice to bake natural sapphires to improve or enhance color. This is usually done by heating the sapphires to temperatures of up to 1800 °C for several hours, or by heating in a nitrogen deficient atmosphere oven for seven days or more. On magnification, the silk due to included rutile needles are often visible. If the needles are unbroken, then the stone was not heated; if the silk is not visible then the stone was heated adequately. If the silk is partially broken, then a process known as low tube heat may have been used. Low tube heat is the process whereby the rough stone is heated to 1300 °C over charcoal for 20 to 30 minutes. This removes gray or brown in the stone and improves color saturation.

Purple sapphires contain the trace element vanadium and come in a variety of shades. Yellow and green sapphires have traces of iron that gives them their color. Pink sapphires have a trace of the element chromium and the deeper the color pink the higher their monetary value as long as the color is going toward the red of rubies. Sapphires also occur in shades of orange and brown, and colorless sapphires are sometimes used as diamond substitutes in jewelry. Salmon-color padparadscha sapphires are orangey-pink, pinkish-orange or pink-orange in color, which often fetch higher prices than many of even the finest blue sapphires. The word 'padparadscha' is Sinhalese for 'lotus flower'. Recently many sapphires of this color have appeared on the market as a result of a new treatment method called "bulk diffusion".

Color shift sapphires are blue in outdoor light and purple under [incandescent] indoor light. Color changes may also be pink in daylight to greenish under fluorescent light. Some stones shift color well and others only partially, in that some stones go from blue to bluish purple. Such color-change sapphires are widely sold as “lab” or “synthetic” alexandrite, which is accurately called an alexandrite simulant since the latter is actually a type of chrysoberyl---an entirely different substance whose pleochroism is different and much more pronounced than color-change corundum (sapphire).

Synthetic sapphire crystals can be grown in cylindrical crystal boules of large size, up to many inches in diameter. As well as gemstone applications there are many other uses:

The first ever laser produced was based on the ruby, the red variety of corundum. While this laser has few applications, the Ti-sapphire laser is popular due to the relatively rare ability to tune the laser wavelength in the red-to-near infrared region of the electromagnetic spectrum. It can also be easily mode locked. In these lasers, a synthetically produced sapphire crystal with chromium or titanium impurities is irradiated with intense light from a special lamp, or another laser, to create stimulated emission.

Pure sapphire boules can be sliced into wafers and polished to form transparent crystal slices. Such slices are used as watch faces in high quality watches, as the material's exceptional hardness makes the face resistant to scratching. Since sapphire ranks a 9 on the Mohs Scale, owners of such watches should still be careful to avoid exposure to diamond jewelry, and should avoid striking their watches against artificial stone and simulated stone surfaces. Such surfaces often contain materials including silicon carbide, which, like diamond, are harder than sapphire and thus capable of causing scratches (Scheel 2003).

Sapphire is highly transparent at wavelengths of light between 170 nm to 5.3 μm, as well as being five times stronger than glass. This leads to use of synthetic sapphire windows in high pressure chambers for spectroscopy.

Wafers of single crystal sapphire are also used in the semiconductor industry as a substrate for the growth of gallium nitride based devices.